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Colestipol is also expected to decrease the absorption of digoxin, and has been shown to produce a clinically significant decrease in the serum half-life of digoxin.

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An increased digoxin dosage may be necessary during pregnancy because of enhanced renal clearance and expanded blood volume.

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Two 12-week, double-blind placebo-controlled studies enrolled 178 and 88 proved trial patients with nyha class ii or iii heart failure previously treated with digoxin, a diuretic, and an ace inhibitor radiance only and randomized them to placebo or treatment with digoxin tablets.

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Fortunately these side effects are infrequent but do occur more often when the digoxin levels rise, particularly over 2.

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